Lecturer, Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences
Dr Lim Ya Chee is a lecturer in PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam. She was a Singapore scholar who studied Biological Sciences in Nanyang Technological University, Singapore. Her master degree was in Medical Molecular Genetics in University of Aberdeen, where she graduated with distinction. After her MSc, she travelled south to do PhD in Melbourne University, Australia. Her PhD work was on a protein kinase, C-terminal Src Kinase Homologous Kinase. She analysed the unique mode of inhibition of this kinase on a family of oncogenic kinase known as the Src Family Kinases via biochemical and biophysical analyses. These kinases are important for regulation of cells, preventing cell growth, proliferation and metastasis that are common characteristic of a cancer cell. Her work concluded with the findings of an allosteric inhibition of Src Family Kinases by C-terminal Src Kinase Homologous Kinase, a mode unique in kinases.
Cancer, Kinase, Phosphorylation
Csk-homologous kinase (Chk/Matk): a molecular policeman suppressing cancer formation and progression
RIPAS Hospital and The Brunei Cancer Centre
Working on genome work to establish clinical guide