Dr Sheba Rani Nakka David


Senior Assistant Professor, Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences


Dr Sheba David obtained her B.Pharm from The Tamilnadu Dr MGR Medical University, Chennai, India in 1998. In 2001 she was awarded her Master with University Gold Medal from Jadavpur University, Kolkata, India. In 2008 she was awarded her PhD Jadavpur University, Kolkata, India. In 2008 Dr David worked as a Post-Doctoral Scientist fellow at the University of Geneva, Switzerland in Professor Kalia’s laboratory where she developed expertise in laser-assisted transdermal drug delivery system techniques. She worked in the School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia. Dr Sheba currently holds the position of Senior Assistant Professor in the Institute of Health Sciences Universiti Brunei Darussalam. Her interests are in Pharmacy, Biomedical and Medical Education.


Pharmacological studies
Natural products
Topical and assisted Transdermal delivery
Medical Education
Check out the latest Video abstract publication: https://www.youtube.com/watch?v=zthCzNL-teY


Silver nanoparticles: Biosynthesis, characterization, and effectiveness for colorectal cancer

Colorectal cancer (CRC) is the third most common cancer-related death reported worldwide. The incidence rate is increasing in Brunei Darussalam. It is therefore vital to develop and investigate novel therapy for colorectal cancer due to the increasing occurrences and the side effects that the radiotherapy and chemotherapy impose. Nanoparticles have been proven to acquire better treatment quality and offer an enhanced therapeutic effect as compared to bulky solids. The use of nanoparticles as therapeutic drug delivery systems has become a prominent research area. This project aims to elucidate the anti-cancer effect of silver nanoparticles synthesized from natural products through in vitro studies. The anti-cancer drug, 5-fluorouracil (5FU) will be used as the standard. The effect of the nanoparticles will be determined quantitatively and the mechanism of action of the nanoparticles in colorectal cancer will be elucidated through in vitro methods of nanoparticles on colorectal cancer cell lines.

Applications Invited

Interprofessional education in Healthcare: exploring the use of simulation for students’ learning.

The use of simulation in medical training offers useful opportunities to improve competence and confidence and is known to assist in minimizing risks to patients, thus improving patient safety. Regarded as an adjunct to clinical learning, the integration of simulation training in the undergraduate medical curriculum is fast becoming recognized as part of an innovative approach in medical education, which aims to stress the importance of clinical competency and proficiency of medical graduates. IPE using Simulation (Sim-IPE) has been practiced in the last decade to enhance student learning in a supportive and safe educational environment. The proponents for simulation put forth a cogent argument that simulation benefits both novice and experts without fear and enhances skill acquisition through experiential learning and stimulates performance reflection. There will be a three-pronged approach for studying the objectives of the research from the students by questionnaires, focus group discussions and individual interviews. Assessors and observers of the Interprofessional Education (IPE) event will also be invited to participate in the FGD to address the study’s objectives.

Applications Invited

Scopus Publications


Google Scholar Citations


Google Scholar h-index


Google Scholar i10-index

Scopus Publications


Check out the latest Video abstract publication: https://www.youtube.com/watch?v=zthCzNL-teY
Ihsan N Zulkipli, Rajan Rajabalaya, Adi Idris, Atiqah Sulaiman, Sheba R David. Clinacanthus Nutans: A Review on Ethnomedicinal Uses, Chemical Constituents and Pharmacological Properties. Pharmaceutical Biology. 2017, 55 (1):1093-1113.http://www.tandfonline.com/doi/abs/10.1080/13880209.2017.1288749
Rajan Rajabalaya, Sheba R David, Jestin Chellian, Gwee Xin Yun, Srikumar Chakravarthi. Transdermal delivery of oxybutynin chloride proniosomal gels for the treatment of overactive bladder. Drug Deliv. 2015, 3:1-10.
Ihsan N Zulkipli, Sheba R David, Rajan Rajabalaya, Adi Idris. Medicinal plants: a potential source of compounds for targeting cell division. Drug Target Insights. 2015; 9: 9 -19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468949
Garuav Gupta, Sheba David, Rohit Kumar Verma. Effect of Rosiglitazone, a PPARγ ligand on haloperidol induced catalepsy. CNS Neuroscience & Therapeutics. 19 (9): 724-725, 2013.


Ya Chee Lim et al, Sheba R David. Parasitic Mistletoes of Genera Scurrula and Viscum: From Bench to Bedside. Molecules. 2016, 21, 1048.
Sheba Rani. N. D., Nazeer Ahmed, Sangeetha Rajaram, Thenmozhi. S., and T. Murugesan. Anti diarrhoeal evaluation of Clerodendrum phlomidis Linn. Leaf extract in rats. Journal of Ethnopharmacology, Elsevier Publication, 68: 315 – 319, 1999. http://www.sciencedirect.com/science/article/pii/S0378874199001038
Gaurav Gupta, Sheba David, Rohit Kumar Verma. Effect of Rosiglitazone, a PPARγ ligand on haloperidol induced catalepsy. CNS Neuroscience & Therapeutics. 19 (9): 724-725, 2013.
G Gupta, R Verma, SR David, DK Chellappan, F Anwar, K Dua. Hepatoprotective activity of moralbosteroid, a steroidal glycoside isolated from Morus alba. Oriental Pharmacy and Experimental Medicine 14 (3): 285-289, 2014.


• Grant type: FIC, Project Title: "Silver nanoparticles: Biosynthesis, characterisation, and effectiveness for colorectal cancer", Investigators (PI/Co-PI): PI
• Grant type: URG, Project Title: "Development and evaluation of self-adhesive matrix tape containing mupirocin for the prevention of exit-site infections and peritonitis", Investigators (PI/Co-PI): PI
• Grant Type: URG, Project Title: "Development and evaluation of Exemestane liquid crystalline gel by topical delivery for the treatment of breast cancer", Investigators (PI/Co-PI): Co-PI
• Grant Type: URG, Project Title: "Investigating the effects of Clinacanthus nutans extracts on cancer cell division", Investigators (PI/Co-PI): Co-PI
• Grant Type: URG, Project Title: "Preferences, perspectives and burden of complementary and alternative medicine use and polypharmacy issues among community-dwelling older people living with chronic illness: a mixed-methods study", Investigators (PI/Co-PI): Co-PI


Latest Video abstract published: https://www.youtube.com/watch?v=zthCzNL-teY
Development of different pharmacological studies
Capacity building

Industry, Institute, or Organisation Collaboration

Academic collaboration with other Universities


Academic paper publication