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Dr Fairuzeta Ja'afar Lecturer, Faculty of Science

About Me Publications

Dr Fairuzeta Ja'afar

Lecturer, Faculty of Science fairuzeta.jaafar@ubd.edu.bn


ABOUT ME

Dr. Fairuzeta binti Haji Md. Ja'afar is currently a lecturer in Physical Chemistry at the Department of Chemical Sciences in the Faculty of Science (FOS) at Universiti Brunei Darussalam, currently teaching Fundamentals in Physical Chemistry, Chemical Thermodynamics, Surface Chemical Phenomena, Molecular Spectroscopy and Quantum Chemistry. She is also involved in teaching a Centre for Lifelong Learning (C3L) course: Sciences for University Study.

Her current research interests cover a wide range from environmental remediation by utilisation of landfill and agricultural waste materials, to chemical analysis and identification of functional groups in natural products and targeted drug delivery in the treatment of diseases using ultrasound and microbubbles. She is always open to discussions pertaining to research, collaborative works and ideas on the above research themes. She is actively looking for masters in research candidates, research assistants and temporary placement research interns.

Dr. Fairuzeta completed her PhD in Chemistry in 2015 from Imperial College London under the supervision of Prof. John Seddon (Department of Chemistry), Dr. Mengxing Tang (Department of Bioengineering) and Prof. Edward Leen (Department of Translational Medicine). The paper "Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis" was published in "Ultrasound in Medicine and Biology" based from the PhD work.

Prior to her PhD, she obtained an MRes in Bioimaging Sciences in 2010 and a BSc in Chemistry in 2009, both from Imperial College London.

In 2004, she received the Ministry of Education A' Level Special Scheme Scholarship, which funded her study in the United Kingdom, from A'Levels in Bedford High School all the way through to her PhD.

EDUCATION

2011-2015 PhD in Chemistry at Imperial College London, United Kingdom
2009-2010 MRes in Bioimaging Sciences at Imperial College London, United Kingdom
2006-2009 BSc in Chemistry at Imperial College London, United Kingdom
2004-2006 GCE A' Levels at Bedford High School Sixth Form, United Kingdom
1999-2003 GCE O' Levels PJN Pg. Hj. Abu Bakar Secondary School, Kuala Belait, Brunei Darussalam
1991-1998 St. James' School, Kuala Belait, Brunei Darussalam

RESEARCH INTERESTS

Utilising waste materials for environmental remediation
Chemical analyses of food products from selected local plants (natural products)
Combining ultrasound and microbubbles for medical imaging and targeted drug delivery
Particle characterization techniques and instrumentation
Microbubble/Nanoparticle cellular interaction: imaging by optical microscopy

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Scopus Publications

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Google Scholar Citations

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Google Scholar h-index


FUTURE PROJECTS

Chemical Analyses of Natural Products derived from Plants native to Brunei Darussalam

Brunei Darussalam is home to some of the most diverse species of flora and fauna. Whilst folklore medicine is commonly known within the community, very little scientific backing and evidence has been published on the natural products derived from the endemic flora and fauna of Brunei Darussalam. The active ingredients found in these natural products may be beneficial or toxic to our health. The aim of this project is to study some selected local food products derived from selected local plants. Identifying the key ingredients in the plant extract may lead to the production of formulations of high commercial values, which may be useful for the local Bruneian entrepreneurs. Chemical analyses and investigation of materials will be helped by methods including, but not limited to chemical assays, heavy metal analyses, nutritional composition, spectroscopy and microscopy. We are actively looking for masters in research candidates, research assistants and temporary placement research interns. Interested candidates should email fairuzeta.jaafar@ubd.edu.bn

Application invited for: MSc in Research

Utilising Waste Materials for Environmental Remediation

In the modern world, handling waste has been a major global concern. In Brunei alone, the amount of waste generated per capita is estimated at 1.4 kg per day. From the total waste produced, almost 70% goes directly to landfills. These waste materials have the potential to be a gold mine of functional materials. Therefore, our interest lies in the development of functional materials from domestic and agricultural waste. In this project, you will research methods of extracting useful materials from waste materials and its possible applications. This may involve making pulp or fertilisers from agricultural waste or small-scale recycling of plastic domestic waste. We are actively looking for masters in research candidates, research assistants and temporary placement research interns. Interested candidates should email fairuzeta.jaafar@ubd.edu.bn

Application invited for: MSc in Research

Combining ultrasound and microbubbles for targeted drug delivery

Microbubbles are micron-sized, inert gas cores stabilised by a biocompatible surfactant in an aqueous dispersion. Introduced into the blood stream via intravenous injection, they react with ultrasonic waves to create very specific signals. This improves the contrast between tissue and the surroundings, effectively “lighting up” the blood in an ultrasonic image. More recently, microbubbles have been shown to be a promising targeted drug delivery vehicle. Drugs could be loaded onto a microbubble surface and upon reaching a specific site for drug delivery, the microbubbles could be popped to release drugs only at that particular site. This method of targeted drug delivery is of particular interest in cancer therapeutics as undesirable side effects could be minimised by only targeting cancerous cells and leaving healthy cells intact during chemotherapy. In this project, you will learn how to create, handle and characterise microbubbles using a variety of analytical methods, namely optical microscopy and ultraviolet spectroscopy. Once proficient in handling and characterising microbubbles, you will investigate methods of loading drugs onto microbubbles via adsorption to microbubble surface. Permeation studies will also be carried out in order to determine efficacy of microbubble-drug permeability as well as the effects on sonoporation on a permeable membrane and to see whether microbubbles improve permeability due to cavitation. We are actively looking for masters in research candidates, research assistants and temporary placement research interns. Interested candidates should email fairuzeta.jaafar@ubd.edu.bn

Application invited for: MSc in Research


RECENT PUBLICATIONS

Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis, Ultrasound Med Biol. 2015 Nov;41(11):2990-3000. doi: 10.1016/j.ultrasmedbio.2015.07.001


TOP PUBLICATIONS

Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis, Ultrasound Med Biol. 2015 Nov;41(11):2990-3000. doi: 10.1016/j.ultrasmedbio.2015.07.001


RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Published the following paper "Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis" in Ultrasound in Medicine and Biology journal which detailed a cheap alternative method to using expensive particle analyzer machines.


CONSULTANCY

Will provide consultancy services upon request. Please contact fairuzeta.jaafar@ubd.edu.bn


Industry, Institute, or Organisation Collaboration

AP Dr. Anwar Usman and Dr. Hartini Yasin, Physical Chemistry Research Team, Department of Chemical Sciences, FOS, UBD
Dr. Sheba Rani Nakka David and Dr. Rajan Rajabalaya from the PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences at UBD


SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

Natural products: Systematic chemical analyses could provide information and scientific backing for improvements in existing formulations for mass production. The information would be of high commercial value for local entrepreneurs seeking to back their health benefit claims for their products.

Waste utilisation: Research into waste utilisation could help minimise waste materials that would go into landfills, as well as provide an avenue for providing raw materials for processing.

Targeted drug delivery: Targeted-drug delivery microbubble work has never been done in Brunei and therefore could open up a new avenue for cancer treatments.