Dr Minhaz Uddin Ahmed

minhaz.ahmed@ubd.edu.bn

Associate Professor, Faculty of Science



                                   

Dr. Minhaz Uddin Ahmed is an Associate Professor of Analytical Chemistry and Biotechnology at the Universiti Brunei Darussalam (UBD). He obtained his Ph.D. in Chemical Materials Science from Japan Advanced Institute of Science and Technology (JAIST) in 2008 under the supervision of Prof. Eiichi Tamiya and later worked as JSPS post doctoral fellow at Osaka University, Japan (2008-2009, with Prof. Eiichi Tamiya), DARPA post doctoral research associate at Duke University, USA (2009-2010, with Prof. April S. Brown) and NSERC post doctoral fellow at INRS-EMT, Canada (2010-2012, with Prof. M. Zourob). His research interests are in the areas of biosensors and diagnostic technologies, and applications to nanobiotechnology, clinical and environmental chemistry. Dr Ahmed is an alumnus of JAIST and a prestigious young participant/fellow of 57th Lindau Nobel Laureate Meeting for Physiology and Medicine, 2007, Germany. In 2008, he was awarded the prestigious Japanese Society for the Promotion of Science (JSPS) young scientist award to work in Graduate School of Engineering of Osaka University. In 2009, he was awarded the United States Defence Advanced Research Project Agency (DARPA) post doctoral fellowship to work at Pratt School of Engineering of Duke University.
He started his own research group in 2012 at science faculty-laboratory for Biosensors, Applied Biotechnology and Halal Science. Apart from his research group, he has been appointed as a "Research Lead" for the BEDB-BRISc funded VBL (Venture business laboratory) at UBD. He is currently supervising a number of graduate and undergraduate students in his laboratory. He is also involved in teaching courses like Biosensors, Biochips and Nanobiotechnology, Modern Analytical Techniques, Nutritional Biochemistry, and Food Chemistry and Chemical Analysis of Foods.
His researches are to develop reliable and simple methodologies that could allow bioanalytical detection to be carried out for various applications, particularly on the aspects of food safety, healthcare and environmental protection which deserve public awareness. He has published numerous articles on the reputed journals of Bioanalytical chemistry like Biosensors and Bioelectronics, Analytical Chemistry, Analyst , Critical review in Biotechnology, Food Chemistry, RSC Advances etc. He is frequently invited to write reviews in top international journals like Biosensors and Bioelectronics which is the principal international journal devoted to research, design development and application of biosensors and bioelectronics in the world.
Dr. Ahmed's works are currently funded by the Brunei Research Council (BRC-10 and BRC-4), Graduate Research Studentships, Cross boundary research programme and host institution grants/scholarships. He has also active research collaboration with Cranfield University of UK, Harvard University of US, INRS-EMT of Canada, University of Chittagong of Bangladesh, Alfaisal University of Saudi Arabia and also RMIT, UNSW, Univ of Queensland of Australia.
Currently, Dr Ahmed is also serving as an Associate Editor of the Q1 journal of RSC Advances published by the Royal Society of Chemistry (RSC), UK. He is also working as a member of the editorial board for the Journal "Sensor International" and ''Biointerface Research in Applied Chemistry''.

Dr Minhaz's Publons ID: PUBLONS LINK for REVIEW AND EDITORIAL WORKS:
publons.com/a/1301472/

Associate Editor: RSC Advances, UK (Q1 Journal) 2015-to date.
Associate Editor: Scientia Bruneiana, 2016- to date.
Editorial Board Member: Sensor International, 2018- to date.
Editorial Board Member: Biointerface Research in Applied Chemistry, 2019- to date.
Editorial Board Member: Bio-engineering International. 2019- to date.
Editorial Board Member: Halal Sphere- 2018-to date

Teaching history:
SC 4363 Modern Analytical Techniques
SC 4368 Biosensors Biochips and Nanobiotechnology
SC 4366 Food Chemistry and Chemical Analysis of Food
SC 2402 Biomarkers, Diseases and Diagnostics
SB 4314 Biotechnology
SB 4340 Nutritional Biochemistry
SR 5101 Advanced Research Skill

EDUCATION

Post Doctoral Training:
JSPS Fellow: Osaka University: 2008-2009, Japan
DARPA Research Associate: Duke University: 2009-2010, USA
NSERC Fellow: INRS-EMT: 2010-2012, Canada

Ph.D. in Chemical Materials Science from Japan Advanced Institute of Science and Technology (JAIST)
(with 18 months of full-time attachment at Graduate School of Engineering, Osaka University, Japan)

MSc and BSc: Biochemistry and Molecular Biology, University of Dhaka, Bangladeh.

RESEARCH INTERESTS

Next Generation Nucleic Acids and Protein Biosensors
Novel Chemical Biology and Biomaterials Approaches
Point-of-Care (POC) Micro Devices
Agro/Food based Applied Biotechnology
DNA/Protein Bioinformatics and Bioengineering

FUTURE PROJECTS

Food (including Halal food) Analysis

As an Islamic country, Brunei Darussalam strives to implement the production of Halal products, especially food, in accordance to Islamic dietary law. However, majority of the commercial food products in Brunei are yet being imported from abroad. Hence, there is a risk on food frauds to be aware of by the public. For example, contamination of food products by traces of pork material.Currently, we are working on a detection system based on Real Time Polymerase Chain Reaction (RT-PCR) or Loop-Mediated Isothermal Amplification (LAMP) that could allow detection of low abundance pork DNA in food samples. In addition, we are also striving to develop novel methodologies based on electrochemical and colorimetric detection systems. In parallel, we are also attempting to improve the efficacy of each methodology by implementing nanotechnology on catalytic mechanisms, biochips production and so on, as well as to develop a detection system that can be utilized for on-site monitoring. Putting it together, our goal is to develop highly sensitive, highly specific, rapid, portable and robust detection systems that can be employed for on-site monitoring during Halal food inspection. Please email: <minhaz.ahmed@ubd.edu.bn> with your interests or study plan. Please also read these to know more about our prior works: Fast and sensitive Real-time PCR based detection of porcine DNA in food samples using Evagreen dye, Food Science and Technology Research, 24 (5) 803-810 (2018). Meat species identification using DNA-luminol interaction and their slow diffusion onto the biochip surface, Food Chemistry, 248, 29-36 (2018). Colorimetric Nucleic Acid Detection on Paper Microchip Using Loop Mediated Isothermal Amplification and Crystal Violet Dye, ACS Sensors, 2 (11) 1713-1720 (2017). Development of fast and sensitive real-time qPCR assay based on a novel probe for detection of porcine DNA in food sample. LWT Food Science and Technology, 84, 686-692 (2017). From market to food plate: current technology and innovations in Halal food analysis. Trends in Food Science and Technology, 58, 55-68 (2016). A novel and sensitive loop-mediated isothermal amplified DNA detection in solution using luminophore dye. Biosensors and Bioelectronics, 86, 346–352 (2016). A label-free electrochemical immunosensor for sensitive detection of porcine serum albumin as a marker for pork adulteration in raw meat, Food Chemistry, 206, 197-203 (2016).


Applications Invited
B.Sc./MSc/Ph.D./Internship

Microbial (Bacterial/Virus) analysis

By targeting specific DNA regions of pathogens, various techniques can be employed for the detection of foodborne and waterborne pathogens for microbial analysis. Currently, we are in collaboration with the Institute of Health Science (IHS) to develop a detection system based on multiple nucleic acid amplification techniques for the detection of bacteria and viruses, including Bacillus cereus, Legionella pneumophila, Staphylococcus aureus, rota virus, noro virus, hepatitis virues, Dengue etc. With the increase of undeclared importation of plants and planting materials from neighboring countries, local plants are more susceptible to dangerous diseases caused by microbes infections. Hence, we are also considering to develop strategies that can allow the detection of harmful microbes to identify infected plants in counter for further damage. Please email: <minhaz.ahmed@ubd.edu.bn> with your interests or study plan.


Applications Invited
B.Sc./MSc/Ph.D./Internship

Clinical diagnostics

Cancer is one of the leading causes of death not only in Brunei Darussalam, but also globally. human chorionic gonadotropin (hCG)is a hormone commonly found in the serum of pregnant women. Presence of significant high level of hCG in men and non-pregnant women can serve as an indication for cancer development. Previously, our laboratory has conducted studies on the detection of hCG based on nanotechnology and electrochemical biosensing approach. By electrochemically quantifying the level of gold nanoparticles that are conjugated to anti-hCG antibody, we could indirectly quantify the level of hCG in serum. Using this strategy as template, we are striving to bring this methodology toward the detection of other biomarkers like sIgA (Saliva), C-reactive protein (CRP), Interleukin 1 Beta, Prostate specific antigen (PSA) etc. Please email: <minhaz.ahmed@ubd.edu.bn> with your interests for updated proposals.


Applications Invited
B.Sc./MSc/Ph.D./Internship
88

Scopus Publications

3205

Google Scholar Citations

29

Google Scholar h-index

50

Google Scholar i10-index

Scopus Publications

GRANT DETAILS

2020-2022: UBD Research Grant as a Principal Investigator; Grant# FIC25; Nanoscaled aptasensors for the detection of multiple biomarkers (Grant amount, 69,500.00 BND: for 2 years).
2020-2022: ASEAN-India S&T Development Fund (AISTDF); as a co-Principal Investigator; Grant# CRD/2019/000158 (Grant amount; 48,28,192 INR: for 2 years).
2018-2020: UBD Research Grant as a Principal Investigator; Grant# FIC10; The development of novel nanostructured biosensors for multiple food allergens (Grant amount, 60,900.00 BND: for 2 years).
2014-2017: Brunei Research Council’s grant; BRC-10 as a Principal Investigator; A versatile signal amplification strategy for biomarkers identification using flexible substrates (Grant amount 2.4 million BND; for 4 years).
2015-2017: Brunei Research Council’s grant; BRC-4 as a co-Principal Investigator; Multidisciplinary research on salivary biomarkers. (Grant amount 1.2 million BND: for 2 years).
2013-2014: UBD Research Grant as a Principal Investigator; Graphene-based platform for the detection for porcine biomarkers (Grant amount 21700.00 BND: for 2 years).
2008-2010: Grant-In-Aid: as a co-P.I.: Japan Society for the Promotion of Science (JSPS) for Scientific Research. (Grant amount 1.5 million Japanese Yen: for 2 years).

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

US PATENTS:

3. USA Patent: US10889854B2: Issue date: 12/01/2021; System and method for immobilization free electrochemiluminescence dye for multi-species detection.
2. USA Patent: US10605806B2: Issue date: 31/03/2020; Electrochemical immunosensor and method of use for analyte detection.
1. USA Patent: US10465244B2: Issue date: 05/11/2019; Electrochemical DNA Biosensor using graphene biochip for species identification.

PATENTS PENDING:
5. Minhaz Uddin Ahmed, Nura Fazira Noor Azam, and Noor Faizah Mohd-Naim; Electrochemiluminescence immunosensor for tropomyosin using carbon nanohorns/Nafion/Fe3O4@Pd screen-printed electrodes (2021)
4. Minhaz Uddin Ahmed, Mohammad Rizwan, Electrochemiluminescence immunosensor for the detection of haptoglobin, US 2020/0217801 A1 (2020).
3. Minhaz Uddin Ahmed, Mohammad Rizwan, and Noor Faizah Mohd-Naim, Nanocomposite modified CdSe QDs electrode for a label-free and highly sensitive ECL immunosensor, US and Brunei Patent Pending (2017).
2. Minhaz Uddin Ahmed, Mohammad Rizwan and David Koh, A nanocomposite based immunosensor for detecting biomarker and method thereof, US and Brunei Patent Pending (2017).
1. Minhaz Uddin Ahmed and Sharmili Roy, System and method for immobilization free electrochemiluminescence DNA detection using a luminophore dye for multi-species detection, Brunei file# BN/N/2016/0064. (2016)

CONSULTANCY

Associate Editor: RSC Advances (2015-to date), Q1 Journal of Royal Society of Chemistry, UK. IF 3.2.
Associate Editor: Scientia Bruneiana (2017-to date)
Editorial Board Member: Sensor International, Elsevier-Science direct Journal (2019-to date)
Editorial Board Member: Biointerface Research in Applied Chemistry (2019-to date)
Editorial Board Member: Bioengineering International.(2019-to date)

Industry, Institute, or Organisation Collaboration

Imperial College, UK
Cranfield University, UK
The University of Queensland, Aus.
Harvard University, USA
Alfaisal University, Saudi Arabia
Universiti Technology Brunei
University of Chittagong, Bangladesh
INRS-EMT, University of Quebec, Canada
CIGIT of Chinese Academy of Sciences, China
Vietnam Academy of Sciences, Vietnam
National University of Singapore, Singapore
National Institute of Technology, Karnataka, India
RMIT University, Australia
UNSW, Australia

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

We are aiming at developing reliable and yet simple methodologies that could allow biological detection to be carried out for various applications, particularly on the aspects of food safety, healthcare and environmental protection which deserve public awareness.