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Dr Lie Chen Associate Professor, Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences

About Me Publications

Dr Lie Chen

Associate Professor, Pengiran Anak Puteri Rashidah Sa'adatul Bolkiah Institute of Health Sciences lie.chen@ubd.edu.bn


ABOUT ME

Dr Chen was a practising pathologist and a teaching academic in China before she decided to pursue her scientific interest full-time in the molecular functional studies of neuromuscular membrane proteins. She first did an MD/PhD double degrees at the University of Bern, Switzerland and then worked as a postdoc at the National Neuroscience Institute in Singapore and later University of Edinburgh, UK. She was a Senior Research Fellow at Edinburgh before joining UBD recently as an Associate Professor in Pathology. Dr Chen has spent the last decade or so working on the physiological properties and molecular regulation on the trafficking of big current potassium (BK) channel. She was also the holder of a number of grants throughout her career. Coming one full circle, at UBD now, in addition to teaching medicine and biomedical science students at UBD, Dr Chen has now started looking into the clinical potentials of using BK channel as a treatment target for neuromuscular diseases, diabete mellitus and breast cancer.

EDUCATION

MD/PhD in Neuroscience (University of Bern, Switzerland)

RESEARCH INTERESTS

Ion channel diseases
Obesity and diabete mellitus
Cancer

580

Google Scholar Citations

12

Google Scholar h-index

12

Google Scholar i10-index


RECENT PUBLICATIONS

1. Chen L, Bi D, Lu ZH, McClafferty H, Shipston MJ. (2017) Distinct domains of the β1-subunit cytosolic N-terminus control surface expression and functional properties of large conductance calcium-activated potassium (BK) channels. J Biol Chem. [Epub ahead of print].
2. Chen L, Duncan P, Macgregor D, Liang Zh and Shipston MJ. (2015) Illuminating the (Electro)physiology of Anterior Pituitary Corticotrophs, in Neuroendocrinology of Stress (eds J. Russell and M. Shipston), John Wiley & Sons, Ltd, Chichester, UK.
3. Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ. (2013) Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. J Biol Chem. 288(18):13136-44.
4. Liang Z, Chen L, McClafferty H, Lukowski R, MacGregor D, King JT, Rizzi S, Sausbier M, McCobb DP, Knaus HG, Ruth P, Shipston MJ. (2011) Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel, SK4. J Physiol. 15;589(Pt 24):5965-86.
5. Chen L, Jeffries O, Rowe IC, Liang Z, Knaus HG, Ruth P, Shipston MJ. (2010) Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem. 285(30):23265-75.


TOP PUBLICATIONS

1. Chen L, Bi D, Lu ZH, McClafferty H, Shipston MJ. (2017) Distinct domains of the β1-subunit cytosolic N-terminus control surface expression and functional properties of large conductance calcium-activated potassium (BK) channels. J Biol Chem.
2. Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ. (2013) Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. J Biol Chem. 288(18):13136-44.
3. Chen L, Jeffries O, Rowe IC, Liang Z, Knaus HG, Ruth P, Shipston MJ. (2010) Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker. J Biol Chem. 285(30):23265-75.
4. Tian L, Jeffries O, McClafferty H, Molyvdas A, Rowe IC, Saleem F, Chen L, Greaves J, Chamberlain LH, Knaus HG, Ruth P, Shipston MJ. (2008) Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels. Proc Natl Acad Sci U S A.105(52):21006-11.
5. Tian L, Chen L, McClafferty H, Sailer CA, Ruth P, Knaus HG, Shipston MJ. (2006) A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J. 20(14):2588-90.
6. Chen L, Tian L, MacDonald SH, McClafferty H, Hammond MS, Huibant JM, Ruth P, Knaus HG, Shipston MJ. (2005) Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing. J Biol Chem. 280(39):33599-609.
7. Chen L1, Schaerer M, Lu ZH, Lang D, Joncourt F, Weis J, Fritschi J, Kappeler L, Gallati S, Sigel E, Burgunder JM. (2004) Exon 17 skipping in CLCN1 leads to recessive myotonia congenita. Muscle Nerve. 29(5):670-6.