Dr Hazwani Suhaimi

hazwani.suhaimi@ubd.edu.bn

Lecturer, Faculty of Integrated Technologies and Program Leader, Faculty of Integrated Technologies

     

     

I obtained my BEng in Chemical Engineering and MSc in Advanced Chemical Engineering with IT and Management from Loughborough University where I worked on a project on storage and preservation of cells for cell-based therapies. This sparked an interest in me to embark on a PhD journey where I was awarded a PhD degree on the glucose diffusivity in tissue engineering membranes and scaffolds and its implications for hollow fibre membrane bioreactor at Loughborough University (2015). The project focused on the investigation of glucose diffusion coefficient in cell-free and cell-seeded tissue engineering membranes and scaffolds in cell culture medium as well as non-dimensionalisation mathematical modelling using both MATLAB and experimental data where prediction of glucose concentration profiles inside the bioreactor was made possible. This would help to effectively design the bioreactor for producing 3D bone tissues. Upon completion, I am appointed to a lectureship in January 2016 at the Faculty of Integrated Technologies, Universiti Brunei Darussalam in Chemical and Process Engineering.

EDUCATION

B.Eng in Chemical Engineering, Loughborough University, United Kingdom (2009)
M.Sc in Advanced Chemical Engineering with IT and Management, Loughborough University, United Kingdom (2010)
Ph.D in Chemical Engineering, Loughborough University, United Kingdom (2015)

RESEARCH INTERESTS

Tissue Engineering, Regenerative Medicine, Transport Process in Porous Media and Healthcare Technology

FUTURE PROJECTS

Hydroxyapatite synthesis from natural clamshell for biomedical applications

The clamshell can be utilized in hydroxyapatite (HAp) synthesis due to the presence of high CaCO3 content. Since the characterization and composition of HAp is comparable to human skeletal and dental structure, HAp has been widely used as bone filler, orthopedic implants coating, drug carrier and other biomedical applications. The common method for HAp synthesis such as chemical precipitation, hydrothermal and chemical vapor have not reported a good control on the morphology of HAp because the processes of nucleation, crystal growth and agglomeration are not well investigated. This research project is aimed to optimize ultrasonication method in synthesizing HAp with the hypothesis that this method can influence seeding, direct the crystal growth as well as agglomeration of the compound structure. The HAp composite will be characterized using Thermogravimetric Analysis (TGA), powder X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) to investigate the morphology, structural and functionalization of the material. The HAp produced will also be tested in biocompatibility with osteoblast cells since the progress of nontoxic nanoparticles and biocompatible has been of interest in recent years to find new material that can support the growth of bone cells.


Applications Invited
PhD/Master

Intelligent wearable anti-sprain system to prevent ankle sprain injury

People around the world participate in many different sports activities for various reasons ranging from personal satisfaction, stress reliever, relaxation and for keeping fit. However, sports is one of the major causes of injuries, which can lead to possible sprains on body parts, disability and even death in severe cases. The most common sports-related injury is ankle sprain. Inadequate treatment of repeated ankle sprains can lead to chronic ankle instability and possibly arthritis in later years. Apart from researches on effective treatment, prevention of ankle sprain injury is also equally, if not, more important. Amongst the many active researches in the field of prevention mechanisms, the design and fabrication of intelligent wearable anti-sprain system is envisioned to help in the foot and ankle biomechanics. This project aims to design, develop and fabricate wearable anti-sprain system which may be attached to relevant parts of the ankle, to detect incorrect landing postures and provide corrective mechanism to prevent such injuries that happen in any sports-related activities. As such, the project shall delve into understanding the reflex mechanisms that happen prior and during ankle sprain, designing suitable sensors, processing unit as well as feedback mechanism. It is envisaged that the device may be embedded in the clothing of athletes (e.g. in a pair of sport legging), and as such, minimally invasive.


Applications Invited
PhD/Master

Diffusion of lactic acid in cell-seeded tissue engineering scaffolds

While many studies in the literature assumed a similar value for the glucose diffusivity in both water and cell culture media (CCM), Suhaimi et al hypothesized the difference in the composition and hydrodynamic properties of both media should give different respective diffusivities. The results shown have proven the hypothesis to be correct. The glucose diffusivity in CCM has been found to be significantly reduced than the one in water due to CCM having a larger dynamic viscosity than water. Another reason may be due to the presence of extra components and therefore the difference in fluid properties of CCM. Although the result from this research does not exclusively apply to all other biological media/cultures since the variation in composition of media may imply a different diffusivity value, it does highlight the danger of assuming glucose diffusivity in CCM as equal to that in water. Similar to the self-diffusivity of glucose in CCM, the effective diffusivity for tissue engineering (TE) materials imbibed in CCM has also been found to be significantly smaller than those in water which is contrary to what have been generally assumed in the previous studies. This further proves that the presence of extra components is a contributing factor to a difference in the effective diffusivity value. Lactic acid is an example of a metabolic waste product produced by cells. As similar to the vascular system in vivo, we should mimic the system in such a way that the diffusion of lactate acid within the scaffold is also monitored. In this way, it may complete the biochemical communication and especially useful in developing a mathematical model that can simulate real situations.


Applications Invited
PhD/Master
8

Scopus Publications

37

Google Scholar Citations

3

Google Scholar h-index

1

Google Scholar i10-index

Scopus Publications

RECENT PUBLICATIONS

Suhaimi H, Das DB (2016) Glucose diffusion in tissue engineering membranes and scaffolds, Reviews in Chemical Engineering, Vol. 32, Issue 6, 629-650, DOI: 10.1515/revce-2015-0021
Suhaimi H, Das DB (2016) Glucose diffusivity in cell-seeded tissue engineering scaffolds, Biotechnology Letters, Vol. 38, Issue 1, 183-190, DOI: 10.1007/s10529-015-1958-2
Suhaimi H, Wang S, Das DB (2015) Glucose diffusivity in cell culture medium, Chemical Engineering Journal, Vol. 269, 323-327, DOI: 10.1016/j.cej.2015.01.130
Suhaimi H, Wang S, Thornton T, Das DB (2015) On glucose diffusivity of tissue engineering membranes and scaffolds, Chemical Engineering Science, Vol. 126, 244-256, DOI: 10.1016/j.ces.2014.12.029

TOP PUBLICATIONS

Suhaimi H, Wang S, Thornton T, Das DB (2015) On glucose diffusivity of tissue engineering membranes and scaffolds, Chemical Engineering Science, Vol. 126, 244-256, DOI: 10.1016/j.ces.2014.12.029
Suhaimi H, Wang S, Das DB (2015) Glucose diffusivity in cell culture medium, Chemical Engineering Journal, Vol. 269, 323-327, DOI: 10.1016/j.cej.2015.01.130
Suhaimi H, Das DB (2016) Glucose diffusivity in cell-seeded tissue engineering scaffolds, Biotechnology Letters, Vol. 38, Issue 1, 183-190, DOI: 10.1007/s10529-015-1958-2

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

4 publications