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Dr Fairuzeta Jaafar Lecturer, Faculty of Science

About Me Publications

Dr Fairuzeta Jaafar

Lecturer, Faculty of Science fairuzeta.jaafar@ubd.edu.bn


ABOUT ME

Dr. Fairuzeta binti Haji Md. Ja'afar is currently a lecturer in Physical Chemistry at the Department of Chemical Sciences in the Faculty of Science (FOS) at Universiti Brunei Darussalam.

She completed her PhD in Chemistry in 2015 from Imperial College London under the supervision of Prof. John Seddon (Department of Chemistry), Dr. Mengxing Tang (Department of Bioengineering) and Prof. Edward Leen (Department of Translational Medicine). The paper ""Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis"" was published in ""Ultrasound in Medicine and Biology"" based from the PhD work.

Prior to her PhD, she obtained an MRes in Bioimaging Sciences in 2010 and a BSc in Chemistry in 2009, both from Imperial College London.

In 2004, she received the Ministry of Education A' Level Special Scheme Scholarship, which funded her study in the United Kingdom, from A'Levels in Bedford High School all the way through to her PhD.

RESEARCH INTERESTS

Biophysical chemistry
Combining ultrasound and microbubbles for medical imaging and targeted drug delivery
Particle characterization techniques and instrumentation
Microbubble/Nanoparticle cellular interaction: imaging by optical microscopy


FUTURE PROJECTS

Microbubbles as targeted drug delivery vehicles

Microbubbles are micron-sized, inert gas cores stabilised by a biocompatible surfactant in an aqueous dispersion. Introduced into the blood stream via intravenous injection, they react with ultrasonic waves to create very specific signals. This improves the contrast between tissue and the surroundings, effectively “lighting up” the blood in an ultrasonic image. More recently, microbubbles have been shown to be a promising targeted drug delivery vehicle. Drugs could be loaded onto a microbubble surface and upon reaching a specific site for drug delivery, the microbubbles could be popped to release drugs only at that particular site. This method of targeted drug delivery is of particular interest in cancer therapeutics as undesirable side effects could be minimised by only targeting cancerous cells and leaving healthy cells intact during chemotherapy. In this project, you will learn how to create, handle and characterise microbubbles using a variety of analytical methods, namely optical microscopy and ultraviolet spectroscopy. Once proficient in handling and characterising microbubbles, you will investigate methods of loading drugs onto microbubbles via adsorption to microbubble surface. Permeation studies will also be carried out in order to determine efficacy of microbubble-drug permeability.

Application invited for: MSc

Combining ultrasound and microbubbles for targeted drug delivery

Microbubbles are micron-sized, inert gas cores stabilised by a biocompatible surfactant in an aqueous dispersion. Introduced into the blood stream via intravenous injection, they react with ultrasonic waves to create very specific signals. This improves the contrast between tissue and the surroundings, effectively “lighting up” the blood in an ultrasonic image. More recently, microbubbles have been shown to be a promising targeted drug delivery vehicle. Drugs could be loaded onto a microbubble surface and upon reaching a specific site for drug delivery, the microbubbles could be popped to release drugs only at that particular site. This method of targeted drug delivery is of particular interest in cancer therapeutics as undesirable side effects could be minimised by only targeting cancerous cells and leaving healthy cells intact during chemotherapy. In this project, you will study the effects on sonoporation on a permeable membrane and to see whether microbubbles improve permeability due to cavitation.

Application invited for: MSc


RECENT PUBLICATIONS

Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis, Ultrasound Med Biol. 2015 Nov;41(11):2990-3000. doi: 10.1016/j.ultrasmedbio.2015.07.001


GRANT DETAILS

Grant type: , Grant Number: , Project Title: , Investigators (PI/Co-PI): , Funding Details: , Start Date: 31/03/2010, End Date: 31/03/2016


RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Published the following paper "Surface Charge Measurement of SonoVue, Definity and Optison: A Comparison of Laser Doppler Electrophoresis and Micro-Electrophoresis" in Ultrasound in Medicine and Biology journal which detailed a cheap alternative method to using expensive particle analyzer machines.


Industry, Institute, or Organisation Collaboration

Dr. Sheba Rani Nakka David and Dr. Rajan Rajabalaya from the PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences at UBD


SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

Targeted-drug delivery microbubble work has never been done in Brunei and therefore could open up a new avenue for cancer treatments.