Dr Sheikh Naeem Shafqat

Naeem Shafqat qualified with a BPharm degree from the University of Karachi, Pakistan in 1996. After finishing BPharm, he joined Park-e-Davis Pharmaceuticals, Pakistan as a Tablet Production Officer. In 1998, to continue his passion for a medical research he went on for a PhD in Medical Biochemistry at the Karolinska Institute, Stockholm, Sweden. Soon after completing his PhD, he joined the University of Oxford (2004-2011) as a post-doctoral fellow, to study the structure-function properties of human metabolic enzymes associated with the pathogenesis of diabetes mellitus and inflammation. At Oxford Naeem got a unique opportunity to train as an expert in modern state-of-art high-throughput protein expression-purification, crystallization and structure biology techniques. His protein structure work has resulted in the determination of over 40 drug/inhibitor-bound human protein structures involved in the pathogenesis of cancer, diabetes and several inflammatory disorders. In 2011, being an expert in protein chemistry/structure biology, he joined the University of Birmingham as a senior research fellow where he studied the structure-function properties of 5alpha-Reductase isozymes and Cytochrome P450 oxidoreductase involved in the pathogenesis of Prostate Cancer and Disorders of Sex Development.
Subsequently, Naeem joined the Biomedical Science programme at the PAPRSB Institute of Health Sciences (IHS), University Brunei Darussalam in 2015 as a Senior Assistant Professor, where he applies his profound knowledge and expertise is studying the structure-function properties of human metabolic enzymes associated with the pathogenesis of inflammation and different hormone dependent cancer forms. In addition, being an experienced academic and an Associate fellow of the higher education academy, UK, Naeem has substantially contributed to the leadership and the delivery of quality teaching and assessment across all years of the Biomedical Science (BHSc), Pharmacy (BhSc), Medicine (BHSc), Dentistry (BHSc) and Nursing & Midwifery (BHSc) programme in line with university frameworks.
In 2016, a new BHSc Pharmacy program was introduced by the PAPRSB IHS, where Naeem got a unique opportunity to contribute to the development of BHSc Pharmacy curriculum in terms of program structure development, module content design, meeting with the program stake holders, and collaboration with the partner institute for establishing a student exchange and discovery year programme for pharmacy student cohorts. Since Aug 2023, Naeem has been appointed as a program leader of the BHSc Pharmacy program where he is responsible to lead the development and improvement of teaching practice and standards within the BHSc Pharmacy program. Furthermore, to enhance the scope of research in pharmacy programme, a master and PhD degree programme by research has been introduced, effective from January 2024.

EDUCATION

• 1993-1996: Bachelor of Pharmacy, University of Karachi, Pakistan
• 1999-2004: PhD in Medical Biochemistry, Karolinska Institute, Stockholm, Sweden.
• 2004 -2011: Post-Doctoral studies, Nuffield Department of Clinical Medicine, University of Oxford, UK
• 2011 -2015: Senior Research Fellow, Center for Diabetes and Metabolism, University of Birmingham, UK
• June 2013: Post Graduate Certificate in Higher Education, UK.
• April 2014: Associate Fellow of the Higher Education Acade

RESEARCH INTERESTS

Structure-function analysis of human Metabolic enzymes

RECENT PUBLICATIONS

1. Protein expression, crystallization and in-silico studies on Cytochrome P450Oxidoreductase wildtype and mutant variants.
Naeem Shafqat*, Siti Nornadhirah Amdani, Long Chiau Ming
Journal of Research in Pharmacy (in press) 2024. *Corresponding Author

2. Assessing consumers’ perception and demand on the community pharmacists’ dispensing
Xuan, Yapp Wen; Goh, Hui Poh; Rehman, Inayat Ur; Shafqat Naeem;…Ming, Long Chiau; Hermansyah Andi. Journal of Pharmaceutical Policy and Practice, 2023, 16(1), 162

3. Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
Awang Jihadi, M.H., Yuda, A., Sukorini, A.I., Hermansyah Andi; Shafqat, Naeem; Tan, C.S., Ming, L.C.
Exploratory Research in Clinical and Social Pharmacy, 2023, 12, 100348

4. Cassava (Manihot esculenta Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry
Mohidin, S.R.N.S.P., Moshawih, S., Hermansyah, A., ...Shafqat N*, Ming, L.C.
Journal of Evidence-Based Integrative Medicine, 2023, 28. *Corresponding Author

5. Role of Immunotherapy in the treatment of cancer
Sia Pei Ling, Long Chiau Ming, Jagjit Singh Dhaliwal, Madhu Gupta, Chrismawan Ardianto, Khang Wen Goh, Zahid Hussain, Naeem Shafqat*
Cancers 2022, 14(21), 5205. *Corresponding Author

GRANT DETAILS

Grant type: , Grant Number: , Project Title: , Investigators (PI/Co-PI): , Funding Details: , Start Date: 31/03/2010, End Date: 31/03/2016

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

-Please refer to publication list on google scholar.
-Crystallize and determined protein 3D X-ray structures of over 40 human metabolic enzymes; Database Pubmed: Author ID: Naeem Shafqat (https://www.rcsb.org)

CONSULTANCY

Worked as a consultant (2016-2017) for the Biotech company “Sengenics”, in collaboration with the UBD, for setting up a “Proteomics facility” for the recombinant production and characterization of medically important human proteins.

Industry, Institute, or Organisation Collaboration

Collaborator:
University of Oxford
University of Birmingham
Karolinska Institute, Stockholm, Sweden
University of Barcelona, Spain
Stanford University & Harvard Medical School, USA

INDUSTRY EXPERIENCE

Park-e-Davis Pharmaceuticals, Pakistan as a Tablet Production Officer. (1997-98)

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

The 3D X-ray protein structures determined in the presence of novel substrate and inhibitors will provide a platform for the discovery of future drug, beneficial for the treatment of hormonal dependent metabolic disorders.