Dr. Abdullahi Abubakar

Dr. Abdullahi Abubakar is a molecular and computational biologist with special interest on proteins implicated in cancers. He graduated with MBBS and was a Registrar of the West African College of Surgeons where he started training in general surgery. Due to his passion for basic medical science research, Dr. Abdullahi left surgery training mid-way and went and did M.Sc. Human anatomy and PhD Molecular Medicine.
His research interest is high-throughput RNA silencing of genes implicated in the various cancers as well as structure-based drug design studies of proteins linked to various cancers. The ultimate aim of his research is to develop experimental and pre-clinical cancer targeted therapy models by developing drugs targeting proteins linked to cancers.

EDUCATION

• PhD Molecular Medicine • National University of Malaysia (University Kebangsaan Malaysia), Malaysia.

• MSc. Human Anatomy • Usmanu Danfodiyo University Sokoto, Nigeria.

• MB, BS (Bachelor of Medicine, Bachelor of Surgery) University of Maiduguri, Nigeria.

• Primaries • West African College of Surgeons.

RESEARCH INTERESTS

The following are my research interests:

1. Interests in computational and structural biology of proteins implicated in cancers including phosphatidylinositol-3-kinase beta, B-Cell lymphoma 2 (BCL-2) and B-Cell lymphoma extra large (BCL-xL) proteins and apoptosis antagonizing factor gene (AATF).

2. Interest in high-throughput gene silencing using short interfering RNA (siRNA) with more emphasis of cancer targeted therapies.

3. I have interest in protein crystallization techniques, bio-processing and fermentation strategies focusing on proteins expression in E. Coli, Pasteurella Multocida in bioreactors for subsequent protein structural biology studies using X-ray diffraction data facilities and synchrotron facilities of our collaborating institutions.

4. I have interest in the analysis of protein X-ray diffraction data from reduction to scaling, protein model building, data refinement and protein analysis using MOSFLM, RefMac, Mercury, coot, phaser and many others CCP4 software package.

RECENT PUBLICATIONS

• A. D. Abdullahi, Jamal, R. A., & Harun, R. A Protein Modelling and Molecular Docking study to enable the Design of Apoptosis Antagonizing Transcription Factor (AATF) Docking Hits. INPRESS: Submitted to Medicinal Chemistry Research (Springer).
• A. D. Abdullahi, Aung, S., Chyang, K. A. P. J., Jamal, R. A., & Harun, R. Identification of Therapeutic Targets for Small Cell Lung Cancer using In Silico Analysis and RNA Interference. INPRESS.
• A. S. Nadiahanis, Abdualkader, M. A., Mohamed, F. & A. D. Abdullahi. Designing Novel PI3K-Γ Inhibitors through Group-Based Quantitative Structural Activity Relationship and Molecular Docking. INPRESS: Submitted to Interdisciplinary Sciences: Journal of Computational Life Sciences (Springer).
• A. D. Abdullahi, Abdualkader, A. M., Samat, N. H. B. A., & Ingale, K. B. The Application of Group-based QSAR and Molecular Docking in the Design of Novel IGF-1R Antagonists. Tropical Journal of Pharmaceutical Research, 14(6), 941-951, ISSN: 1596-5996, 2015.
• A. D. Abdullahi, Nadiahanis, A. M. A. A., Yauri, B. Y. M., Mohamed, F., Kasmuri, A., Aljarbou, A., Altuwaijri, S., Harun, R., & Helal Uddin, A. B. M. Molecular Docking and Group-based QSAR in the Design of Novel p70 Ribosomal S6 Kinase (p70S6K) Inhibitors. Journal of Applied Pharmaceutical Science, 4(6), 16-24, 2014.
• Nadiahanis, A. S., Abdualkader, M. A., Mohamed, F., & A. D. Abdullahi. Group-based Quantitative Structure Activity Relationship (G-QSAR) Analysis and Molecular Docking of B-cell Lymphoma Extra-large (Bcl-xl) Inhibitors. International Journal of Pharmacy and Pharmaceutical Sciences, 6(5), 2014.
• Nadiahanis, A. S., Mohamed, F., & A. D. Abdullahi. Group-based Quantitative Structure-Activity Relationship (G-QSAR) Analysis and Molecular Docking of B-Cell Lymphoma 2 (BCL-2) Inhibitors. Journal of Science and Technology in the Tropics (JOSTT); Special Issue Supplement, 2013.
• Merzouk, A., Ghawi, A. M., Abdualkader, A., A. D. Abdullahi & Alaama, M. Anticancer Effects of Medical Malaysian Leech Saliva Extract (LSE). Pharm Anal Acta S, 15(2), 15:2, 2012.
• Ibrahim, K., A. D. Abdullahi, Leong, N. C., Murad, N. A. A., Mokhtar, R. J. N. N., Wan Ngah, W. Z., & Harun, R. In silico Homology Modelling and Identification of Tousled-like Kinase 1 Inhibitors for Glioblastoma Therapy via High-throughput Virtual Screening Protein-ligand Docking. INPRESS
• Malami, S. A., Pindiga, U. H., Abimiku, B. A., Dauda, A. M., Mungadi, I. A., A. D. Abdullahi, Dauda, A., & Sahabi, S. M. A Descriptive Retrospective Study of the Pattern of Malignant Diseases in Sokoto, Northwestern Nigeria 1999-2004. Journal of Medical Sciences, 7(6), 1033-1038, 2007.

TOP PUBLICATIONS

• A. D. Abdullahi, Abdualkader, A. M., Samat, N. H. B. A., & Ingale, K. B. The Application of Group-based QSAR and Molecular Docking in the Design of Novel IGF-1R Antagonists. Tropical Journal of Pharmaceutical Research, 14(6), 941-951, ISSN: 1596-5996, 2015.
• A. D. Abdullahi, Nadiahanis, A. M. A. A., Yauri, B. Y. M., Mohamed, F., Kasmuri, A., Aljarbou, A., Altuwaijri, S., Harun, R., & Helal Uddin, A. B. M. Molecular Docking and Group-based QSAR in the Design of Novel p70 Ribosomal S6 Kinase (p70S6K) Inhibitors. Journal of Applied Pharmaceutical Science, 4(6), 16-24, 2014.
• Nadiahanis, A. S., Abdualkader, M. A., Mohamed, F., & A. D. Abdullahi. Group-based Quantitative Structure Activity Relationship (G-QSAR) Analysis and Molecular Docking of B-cell Lymphoma Extra-large (Bcl-xl) Inhibitors. International Journal of Pharmacy and Pharmaceutical Sciences, 6(5), 2014.
• Nadiahanis, A. S., Mohamed, F., & A. D. Abdullahi. Group-based Quantitative Structure-Activity Relationship (G-QSAR) Analysis and Molecular Docking of B-Cell Lymphoma 2 (BCL-2) Inhibitors. Journal of Science and Technology in the Tropics (JOSTT); Special Issue Supplement, 2013.
• Merzouk, A., Ghawi, A. M., Abdualkader, A., A. D. Abdullahi & Alaama, M. Anticancer Effects of Medical Malaysian Leech Saliva Extract (LSE). Pharm Anal Acta S, 15(2), 15:2, 2012.